Making your mark

Your Mark Is My Dirt: Impact of Email Signatures on Decision Making

In order to text mine email data it is important to address the substantial amount of noise usually contained in the data. This noise can skew the results of data mining and so reduce the effectiveness and efficiency of decision support systems that use these techniques. Ideally the noise is removed in pre-processing. The paper presents a case study of a series of steps to progressively clean a...

On your histone mark, SET, methylate!

Lysine methylation of histones and non-histone proteins has emerged in recent years as a posttranslational modification with wide-ranging cellular implications beyond epigenetic regulation. The molecular interactions between lysine methyltransferases and their substrates appear to be regulated by posttranslational modifications surrounding the lysine methyl acceptor. Two very interesting exampl...

Making Your Website Usable

Making your own retrograde carrier.

One of the problems faced by manufacturers is the difficulty in constructing a robust and reliable, angled applicator tip. This can be overcome by handmaking your own retrograde carrier. The applicator tip may be bent to about 50 degrees and, if a kink occurs while bending the tip, it can be replaced easily by a new modified needle. Because the wire used is flexible, it can adapt to the bend wi...

On your mark, get set: brainstem circuitry underlying saccadic initiation.

Saccades are rapid eye movements that are used to move the visual axis toward targets of interest in the visual field. The time to initiate a saccade is dependent upon many factors. Here we review some of the recent advances in our understanding of the these processes in primates. Neurons in the superior colliculus and brainstem reticular formation are organised into a network to control saccad...